Toxicology Data Scientist Intern

Key Skills

Algorithms, Analytical and Problem solving, Python Programming, R Programming, SQL

Job Description

At Johnson & Johnson, we use technology and the power of teamwork to discover new ways to prevent and overcome the world’s the most significant healthcare challenges. Our Corporate, Consumer Health, Medical Devices, and Pharmaceutical teams leverage data, real-world insights, and creative minds to make life-changing healthcare products and medicines. We're disrupting outdated healthcare ecosystems and infusing them with transformative ideas to help people thrive throughout every stage of their lives. With a reach of more than a billion people every day, there’s no limit to the impact you can make here. Are you ready to reimagine healthcare?

Here, your career breakthroughs will change the future of health, in all the best ways. And you’ll change, too. You’ll be inspired, and you’ll inspire people across the world to change how they care for themselves and those they love. Amplify your impact. Join us!

Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development is focused on novel targets for autoimmune and inflammatory diseases, but also includes CNS, oncology and metabolic disorders. For more about Janssen Pharmaceuticals, Inc., one of the Pharmaceutical Companies of Johnson & Johnson, visit http://www.janssenpharmaceuticalsinc.com

Qualifications

• We currently have one Summer Intern position in the Biochemical Toxicology Group (La Jolla, CA) to participate in studies focused on concordance of preclinical toxicity and clinical adverse drug reactions.
• Preclinical toxicology studies play an essential role in drug development for the evaluation of potential safety risks. Nonetheless, numerous analyses revealed that the safety phenotypes were not adequately predicted in animals, which remains a major contributor to drug attrition in the late development stages.
• To improve our ability to predict human risk, there is a need to systematically evaluate and quantify the concordance of adverse events (AEs) between animal models and clinical studies. In this work, we aim to integrate preclinical and clinical toxicological data archived in different sources and analyze all phenotypic events in preclinical species and humans to create a database of concordances with statistical metrics.
• Experimental variables such as drug type, dose, exposure, administration route, and tox severity grade level will also be retrieved and explored in the analysis.
• This powerful data driven approach that computes both statistical significance and predictive power, will provide useful information to help understand (non)translatable AEs across species.
• The results can be valuable for assessing the likelihood of potential clinical risk based on animal observations, guiding species selection, as well as improving in vitro/in vivo work for new and better preclinical safety markers for endpoints with low concordance.
• This assignment offers the opportunity to work as part of a cross-functional team in a pharmaceutical laboratory setting.
• This direct exposure will allow the student to participate in the planning, execution, analysis and reporting under the guidance of experienced scientists. Interested candidates should have a strong desire to learn the drug development process and contribute to improving the health of people worldwide.

Qualifications

• Current master or PhD students with statistics and programming skills (R and Python), and familiar with Pharmaceutical Sciences and other life science related fields.
• Candidates must be self-motivated, reliable and have excellent problem solving skills.
• Qualified candidates must have the ability to work both independently and as part of a team and have strong interpersonal and analytical skills.
• Good verbal and written communication skills are required. Candidates must have authorization to work in the US.

At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.