Senior Scientist ? Translational Modeling and Simulation

Key Skills

Apache Hadoop, C Programming, C++, Data science techniques, Java Programming, Machine learning techniques, MapReduce, Python Programming, PyTorch, R Programming, Scala Programming, SQL, TensorFlow

Job Description

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies, is recruiting for a Senior Scientist, Translational Modeling and Simulation, located in Spring House, PA or San Diego, CA. 

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The candidate is expected to utilize translational pharmacokinetic (PK) and pharmacodynamic (PD) modeling to drive project team decisions from early discovery through early clinical studies, as well as contribute to guiding modeling and simulation strategies within the organization.

The candidate will be a key member of discovery and early development project teams and interact closely with biology, chemistry, clinical, and other team members to help design the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to inform candidate selection and dosing recommendations. Modeling approaches used may include physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling

Qualifications

• PhD in Pharmacology, Engineering, Mathematics, Physics, or related fields is required with at least 3 years of relevant work experience. Exceptional candidates with Master’s degree and at least 10 years of relevant experience may also be considered.
• Familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is preferred
• Proven skills in mathematical modeling and simulation, supported by peer-reviewed publications record is highly desired. 
• The candidate must possess excellent interpersonal, organizational, oral/written communication and teamwork skills.
• This position can be based in Spring House, PA, or San Diego, CA and may require approximately 10% travel.