Associate Director Computational Biologics Sequence Discovery and Design, Predictive Sciences

Key Skills

Bioinformatics, Data pipelines, Data science techniques, Design, Leadership Skill, Machine learning techniques, Teamwork

Job Description

Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission. 

The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company.  We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

JOB DESCRIPTION

We are seeking a creative and collaborative scientist and technologist to lead a computational sequence identification team to help us discover and design novel biologics. You have expertise in building and scaling next-generation sequencing technologies, pipelines, and workflows that connect to machine learning and predictive models and integrate with automation and functional assays to drive closed-loop design of protein therapeutics with desired binding characteristics and biological activity. This role provides the opportunity to work on multidisciplinary teams to solve challenging problems in the discovery and design of new biologics.

We are deeply passionate about what we do here at Bristol Myers Squibb because we know that our work helps deliver truly innovative and life-changing therapies for complex diseases of unmet medical need. If this inspires you as well, we’re excited to have you join us!

RESPONSIBILITIES

• Lead a high-functioning team focused on sequence identification and characterization of antibodies and related biologics in support of BMS’ pipeline of therapeutic programs
• Leverage automation, data science, bioinformatics, and machine learning to expand the throughput of antibody screening platforms, including data curation, analysis and interpretation of large data sets
• Partner with project teams to build workflows and pipelines around analytical frameworks for antibody repertoire sequencing
• Present strategies, approaches, results, and conclusions to a publishable standard in static and interactive formats
• Collaborate with discovery biotherapeutics teams to develop an integrated approach for identifying molecules with novel binding and functional properties to progress
• Coach, mentor, and develop talent
• Establish and strengthen the interface between teams, including streamlining communication, operations, and data systems
• Participate in authorship of scientific reports, and present methods and conclusions to publishable standards

BASIC QUALIFICATIONS

• Bachelor's Degree in biochemistry, biophysics, computer science, engineering, or related field and12+ years of academic / industry experience
• or Master's Degree in biochemistry, biophysics, computer science, engineering, or related field and 10+ years of academic / industry experience
• or PhD in biochemistry, biophysics, computer science, engineering, or related field and 8+ years of academic / industry experience
• 4+ years of leadership experience

PREFERRED QUALIFICATIONS

• PhD in biochemistry, biophysics, computer science, engineering, or related field with 10+ years of experience, with half of that time being in biopharma or biotechnology industries.
• Demonstrated expertise in biotherapeutic sequencing technologies and characterization.
• Experience scaling workflows and processes that leverage high-throughput technologies.
• Deep understanding of binding kinetics, affinity, epitope, and mechanism of action, using surface plasmon resonance (SPR), or orthogonal technologies such as BLI, ITC, ELISA.
• In depth understanding of antibody sequence, structure, and antigen engagement.
• Excellent problem-solving skills and teamwork.
• Strong communication, data presentation, and visualization skills.
• A track record of successful people and team leadership, with a focus on developing talent.
• Experience with laboratory information management systems (LIMS) is desired.

The starting compensation for this job is a range from $179,000 to $220,000 plus incentive cash and stock opportunities (based on eligibility).