Post Doctoral Biotherapeutics

Key Skills

Aartificial intelligence, Algorithms, Deep Learning, Jupyter Notebook, Machine learning techniques, MATLAB Programming, Python Programming, R Programming

Job Description

As a Postdoctoral Scientist, you will be a primary driver of fundamental research and technology innovation in the area of In silico Antibody Discovery and Virtual Screening. In particular, we are recruiting for creative computational scientists to enable development of computational workflows to identify and optimize discovery and design of biotherapeutics using the deep learning approaches in combination with computational biophysics/chemistry. The ideal candidates for this position will be independently driven computational biophysicists / chemists / biologist who are proficient in AI/ML (particularly, generative algorithms), molecular modeling and simulation based approaches to generate novel antibody sequences and optimize them for antigen binding as for developability in a synergistic manner. The scientists will be expected to initiate and publish research findings to internal and external scientific community.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities

Enable in silico antibody discovery using machine learning as well as computational biophysical approaches.

Implement structure-based strategies to generate and optimize monoclonal, bispecific and multi-specific antibody formats and contribute to discovery processes.

Work with multi-disciplinary groups of experimentalists, including those involved in protein expression, purification, biophysical characterization and drug development.

 Proficiently execute assigned tasks in AI/ML, data science, bioinformatics, homology-based antibody modeling and molecular simulations.

Establish an international reputation in area of expertise with publication and conference participation; represent BIPI as a scientific leader in field of expertise at both internal and national/international conferences, meetings and organizations.

Comply all applicable regulations, performing all work in a safe manner; maintain proper records in accordance with SOP’s and policies.

Contribute towards mentoring colleagues

Other tasks assigned by the mentor time to time

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Requirements

PhD degree in computational biophysics, chemical engineering, bioinformatics or related discipline with no more than 1 years of postdoctoral experience

Familiarity with scientific computing and computer programming language in Python

Familiarity with mathematical modeling software packages such as R, Jupyter notebook or Matlab.

Familiarity with Molecular modeling and simulation packages such as MOE, BIOVIA, Schrodinger, NAMD, Gromacs and Amber.

Strategic research planning ability and excellent written and oral presentation skills

Familiarity with current topics in AI/ML including different kinds of generative models

Desired Skills, Experience and Abilities

Original thinking, high level of motivation, and ability to work independently as well as collaboratively

Demonstrated creativity and initiative in driving cutting edge research and good publication record

Demonstrated knowledge of Antibody/Protein structure-function, hands-on experience with computer programming, machine learning, molecular modeling, simulations and data analyses

Ability to collaborate with experimentalists and colleagues interested in molecular biophysics

Exceptional written and oral communication skills

Our Company

At Boehringer Ingelheim we develop breakthrough therapies that improve the lives of both humans and animals. Founded in 1885 and family-owned ever since, Boehringer Ingelheim takes a long-term perspective. Now, we are powered by 52,000 employees globally who nurture a diverse, collaborative and inclusive culture. We believe that if we have talented and ambitious people who are passionate about innovation, there is no limit to what we can achieve.

Why Boehringer Ingelheim?

With us, you can grow, collaborate, innovate and improve lives.

We offer challenging work in a respectful and friendly global working environment surrounded by a world of innovation driven mindsets and practices. In addition, learning and development for all employees is key, because your growth is our growth.

Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment, which benefits our employees, patients and communities.

Want to learn more? visit https://www.boehringer-ingelheim.com