Senior Computational Chemist - Tumor Targeted Delivery Drug Discovery

Key Skills

Computational Algorithms, Effective communication skills, Presentation skills

Job Description

Senior Computational Chemist - Tumor Targeted Delivery Drug Discovery

Waltham, MA

Do you want to be at the cutting edge of innovation that will lead to state-of-the-art therapies for cancer? At AstraZeneca, we turn ideas into life changing medicines. Our pioneering oncology pipeline enabled by transformative technologies drives us forward. Working here means being ambitious, thinking big and working together to make the impossible a reality for the patients.

We are currently seeking a highly skilled computational chemist who is passionate about drug discovery to join our Tumor Targeted Delivery (TTD) computational chemistry group. As a computational chemist in this group, you will be a key member of our interdisciplinary drug discovery project teams across a range of new modalities, you will use your expertise in computational chemistry to influence project directions and help accelerate project progression. Reporting to the group leader of computational chemistry within TDD, you will have the chance to work closely with an established group of computational chemists at AstraZeneca to deliver AstraZeneca's drug pipeline.

Responsibilities:

• Conduct modern computational chemistry experiments independently and in a timely manner to influence drug discovery project direction.

• Generate testable hypotheses to drive medicinal chemistry design strategies using state-of-the-art structure-based and ligand-based modeling approaches.

• Apply latest computational hit identification methods to discover new chemical matters for new drug targets.

• Develop and refine new computational methods through collaborations with internal and external computational groups.

• Build strong working relationships with scientists from other disciplines, including structural biology, biophysics, ADME/DMPK and safety sciences as part of the wider drug discovery project teams.

• Effectively communicate scientific results through internal and external presentations and publications.

• Supervise PhD students and postdocs through academic collaborations

Qualifications:

• A Ph.D. in computational chemistry or a related field

• Deep knowledge in one or more areas of the computational chemistry discipline, such as molecular dynamics, quantum mechanics, structure-based drug design, ligand-based drug design, virtual screening, etc.

• Proficiency in some molecular modeling software packages and programming languages commonly used in computational chemistry.

• Excellent problem-solving skills with a proven track record in publications and presentations.

• Working knowledge of Antibody Drug Conjugates and understanding of drug design basic concepts are highly desirable.

Site Description

Our Waltham, MA facility builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field, and it is only a short drive from Boston, MA. It is filled with innovative technology. Our work areas were built to facilitate teamwork, interaction and cross functional science. We believe employees benefit from being challenged and inspired at work.

The Boston R&D site, located in Waltham, MA, is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space. Site amenities include:

• Modern 64-acre campus nestled in 200+ acres of nature conservation land & hiking trails

• Flexible, agile lab design with co-located write-up space

• Vibrant site community with activities, clubs, sports & games

• Onsite business & meeting center, office, AV & catering support

• Onsite outdoor activities (e.g. frisbee golf, garden club, volleyball, etc.)

It is a great place to work in the heart of one of the world’s most vibrant research cities!

So, what’s next?

• Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!