Principal Scientist Bioinformatics, Pioneering Medicines

Key Skills

Analytical and Problem solving, Bioinformatics, Drug Discovery, Effective communication skills, Genomic data, Immunology, Python Programming, R Programming

Job Description

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. 

About Flagship Pioneering:

Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.

Position Summary:

We are seeking a bioinformatics expert to join the Pioneering Medicines Translational Sciences Team. This person will lead the computational efforts on drug discovery programs, integrate, analyze and interpret omics data and effectively communicate results to impact target discovery, translational and patient stratification efforts across disease areas. This individual will collaborate with the translational research, biology, ADME/Tox and early development teams, in order to help execute on research program strategy.

Key Responsibilities:

• Lead Translational Bioinformatics projects in various areas, including but not limited to oncology/IO, cardiovascular, pulmonary, renal and metabolic diseases.
• Propose, evaluate and champion state-of-the-art computational omics approaches to answer key biological questions.
• Mine genomics datasets to identify novel targets for small molecule and biological therapies; design, integrate and perform appropriate analyses of such data for translational needs including biomarker identification/target discovery, validation support and patient stratification.
• Ability to analyze a rich suite of data modalities: bulk and single cell RNAseq/genomics, proteomics, and state-of-the-art modeling techniques, tailored to specific programs and disease areas.
• Work closely with the in-vivo, in-vitro and translational research teams to translate biological questions into analytical solutions, including influencing experimental design, analyzing data and visualizing results.
• Collaborate with other scientists in a global matrixed dynamic environment fostering innovation and advance project activities. Develop and maintain external relationships/contacts.
• Deliver impact to projects by identifying technical trends, both internal and external to your subject area.

Unique Opportunities:

• Work in a highly-stimulating, challenging and interdisciplinary research environment with opportunities for active learning and development.
• Ability to impact therapeutic strategies of potentially revolutionizing therapies.

Minimum Requirements:

• Ph.D in Bioinformatics, Computational Biology, Biological Sciences, or related discipline and 3+ years of industry experience as a bioinformatics representative on drug discovery programs.
• Understanding of biology and/or translational research and ability to address biological questions using computational approaches; in-depth knowledge of cancer genomics, tumor immunology, immunology or other related areas.
• Succesful track record collaborating with cross-functional scientific teams.
• Experience with state-of-the-art methods for next generation sequencing data.
• Experience integrating genetic, genomic and pathway/network datasets with novel experimental data to derive biological understanding.
• Fluency in R, Python or any other broadly used programming languages.
• Excellent problem-solving, teamwork and communication skills, with an ability to effectively interact with people in a dynamic matrix environment, both internally and externally.
• Strong scientific curiosity and initiative.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.