Senior Scientist I, Computational Chemistry

Key Skills

Bash scripting, C Programming, Cheminformatics, Data Analysis, Data science techniques, Design, Drug Discovery, Effective communication skills, High performance computing- HPC, Java Programming, Machine learning techniques, Mentoring, Python Programming, R Programming

Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a key contributor to our Computational Chemistry team, you will:

• Partner with multidisciplinary, collaborative teams to design, optimize, and accelerate the discovery of novel drug candidates using computational methods.
• Mentor teams of computational chemists as part of an integrated computational chemistry effort.
• Enhance our understanding of SAR from Ro5 and bRo5 projects and influence the team strategy using state of the art computational methodologies including structure-based and machine learning approaches.
• Using structural datasets, train interpretable machine learning models for protein-protein interfaces (PPI) and predict protein complex affinity to create screening and optimization strategies for PPI inhibitors and/or stabilizers.
• Using Ro5 and bRo5 compound datasets, train interpretable machine learning models for chemical properties and activities to be used for multi-parameter optimization of compound designs.
• Run computational chemistry software and models in a cloud high-performance computing (HPC) environment to rapidly run computational experiments enabling data-driven decision making.
• Provide innovative ideas and models to challenge and shape project thinking. Serve as lead computational chemistry representative on drug discovery pipeline projects.

Required Experience, Skills, and Education:

• PhD. in computational chemistry or related field.
• Minimum 5 years of computational chemistry experience in the biotechnology/pharmaceutical industry
• Expert-level knowledge of contemporary computational chemistry methods and their use in protein-ligand analysis and drug design.
• In-depth experience with computational chemistry, cheminformatics, data science, machine learning software.
• Scientific programming or scripting in Bash, Python, R, Java, C languages, or similar languages.
• Excellent team and written communication skills. Experience in working with teams to complete projects.
• Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, fast-paced environment.

The expected salary range for this role is $150,000 to $190,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

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