Computational Clinical Scientist II, Translational Medicine

Key Skills

Bioinformatics, Data Analysis, Effective communication skills, Presentation skills, Python Programming, R Programming, Software Development, Statistics

Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

In this role, you will work within our Translational Medicine group analyzing and interpreting molecular and clinical data. Analysis will focus on using genomic, protein and other targeted assays to identify and validate predictive biomarkers. The computational clinical scientist will work on various projects in different phases of drug development and contribute to the cross-functional team which includes other bioinformaticians, program leads, medical monitors, biostatisticians other pre-clinical scientists.

The Opportunity:

As a Computational Clinical Scientist II in Translational Medicine, you will:

• Integrate multiple data sources including circulating tumor DNA, patient enrollment data, molecular profiling (RNA/DNA sequencing outputs), multiplex immunohistochemistry to identify and validate new biomarkers for candidate drugs
• Support the development of biomarker related aspects of the trial design where bioinformatic analysis is required, including study protocols, lab manuals, clinical study reports, and other regulatory documents
• Work with internal groups, contract research organizations and collaborators to deliver validated biomarker data and analysis
• Work with biomarker scientists to support analysis of biomarker readouts (summary statistics, and visualization of efficacy in molecular subgroups)
• Collaborate with preclinical bioinformaticians to design, analyze and interpret experiments to validate biomarkers, understand compound mechanism of action, and identify biomarkers for patient selection and target engagement

Education, Experience and Skills Requirements:

• M.S. or Ph.D. in bioinformatics, molecular biology, data science or a related field with emphasis on biological data analysis
• 2+ years of pharmaceutical or biotech experience in bioinformatics focused on oncology, immunology, or a related field
• Proficiency and experience programming using Python and/or R necessary
• Proficiency in visualizations and faceting of molecular data necessary (oncoplots, heatmaps, PCA, etc.)
• Experience with molecular data generated from clinical trial samples strongly preferred
• Experience with efficacy, baseline demographic, and other outcome data generated in a clinical trial strongly preferred
• Excellent scientific and business communication skills, strong interpersonal/collaboration skills and planning skills
• Experience with statistical methods i.e. survival analysis, and causal inference preferred
• Expertise in bioinformatic analysis of cancer signaling pathways and driver mutations preferred
• Familiarity with large genomic data sets (GDC, TCGA, etc.) preferred
• Experience in tools to analyze cancer genomics data types (RNA, WES, ctDNA, etc) and common tool outputs (GATK, Salmon, OncoKB, VEP, etc.) preferred
• Familiarity with clusters, containers, and cloud computing infrastructure for data processing, analysis, and storage preferred
• Development with professional software development systems and methods (e.g. IDE’s, ticketing systems, version control systems) preferred

The expected salary range for this role is $130,000 - $147,500 - $165,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

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