Post Doctoral Fellow - Bioinformatics/Proteomic/Metabolomic

Key Skills

AWS, Bioinformatics, Effective communication skills, Git, Machine learning techniques, RNA-seq Data processing

Job Description

What you will do

Let’s do this. Let’s change the world. This is an opportunity to join Amgen’s Biologic Therapeutic Discovery organization as a Postdoctoral fellow. In this vital role, you will be enabling and participating in the development of predictive models to guide the discovery and optimization of therapeutic proteins. You will be embedded in a technologically diverse team, working with leading biotechnology and machine-learning experts to solve some of the most difficult problems in large-molecule discovery. You will also have the opportunity to write manuscripts, publish them in leading journals, and present data in internal and external settings, including oral and poster presentations at scientific conferences.

Amgen is advancing innovative methods for designing and optimizing protein therapeutics using a combination of experimental and computational techniques. We are seeking a postdoctoral fellow to perform bioinformatic analysis and multi omic integration of data generated from an immunogenicity screening platform. The postdoctoral fellow will have two co-mentors, one with expertise in immunology and the other in Machine Learning. This position is part of a Center of Excellence based at Amgen’s site in Burnaby, BC, Canada.

• Serve as the bioinformatics lead on a collaborative project focused on characterizing induced immune responses in an in vitro immunogenicity model

• Perform analysis of scRNAseq and proteomics data

• Perform rational multi omic integration of resulting data

• Use the relevant data to generate training sets for Machine Learning

• Play a key role in data collection, model training, and deployment for property prediction

• The postdoctoral fellow will also receive personalized training in relevant areas of Machine Learning or immunology, as needed.

Win

What we expect of you

We are all different, yet we all use our outstanding contributions to serve patients. The dedicated and innovative professional we seek is a postdoctoral fellow with these qualifications

Basic Qualifications:

• Doctorate degree in bioinformatics or a related field

• Understanding of basic concepts of immunology

• Significant experience in single-cell RNAseq analysis pipelines

• Excellent communicator able to write and speak about technical concepts to business, technical, and lay audiences

Preferred Qualifications:

• Experience in proteomic/metabolomic analysis pipelines

• Experience with multi omic integration strategies

• Understanding of B cell biology and de novo immune response mechanisms

• Experience with Machine Learning, or willingness to learn on the job

• Experience with cloud computing (i.e., AWS)

• Experience with Git or similar version control tools

• Proficiency in programming

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans and bi-annual company-wide shutdowns

• Flexible work models, including remote work arrangements where possible