Research Associate III, Bioprocess Development

Key Skills

Data extraction, Metabolomics, Molecular biology, Python Programming, SQL Server

Job Description

Position at Seagen

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Position Summary:

The BioProcess Development department at Seagen is seeking a highly motivated individual to work in the Cell Line Development (CLD) group. The Research Associate will support development of cell lines used to produce therapeutic proteins for clinical trials and future commercial applications while engaging cutting-edge technologies to characterize and advance our platform. The CLD team uses modern molecular biology and aseptic cell cultures techniques to create recombinant CHO cell lines for biologics production. As a key stage-gate between research and bioprocess development, CLD functionality is critical to the establishment and advancement of CMC project timelines and deliverables. The CLD team works in a highly collaborative, cross functional CMC setting involving many functional areas.

Principal Responsibilities:

• Analyze recombinant protein expression using high-throughput analytical methods
• Assist with ongoing cellular and metabolic profiling of antibody-producing cell lines using cell-based and protein chemistry assays
• Aid in the engineering of expression vectors using standard molecular biology techniques
• Bioinformatic data generation, management, and analysis for new technology development
• Compile and analyze data, keep accurate records of experiments and results
• Provide updates and present data in team and group meetings
• Engage in all aspects of maintaining mammalian cell lines including passaging of cells, preparation of tissue culture reagents, and helping with laboratory upkeep and restocking

Requirements:

• Bachelor’s degree in Biology, Biochemistry, Bioengineering or related science major and 5+ years experience in a related field or Master's degree in related field and 2+ years experience
• Hands-on experience with mammalian cell culture using aseptic techniques
• Working knowledge of python, R, and SQL
• Experience with basic molecular biology techniques: PCR, DNA cloning and sequence analysis
• Strong organization, time management and problem-solving skills
• A team player with good communication skills, desire to achieve team and individual goals

Desired Skills:

• Familiarity with general protein chemistry and cell-based assays including protein extraction, western blotting, and reporter assays
• Basic understanding of mammalian cell biology and metabolism
• Relevant experience in the biotechnology industry or academic laboratory