Job Description

The Director/Senior Director, DMPK will set strategy and lead activities associated with design, management, analysis, and interpretation of in vitro and in vivo experiments of absorption, distribution, metabolism, and elimination for Valo’s internal cardiovascular indication focused small molecule drug discovery programs, as well as provide domain area expertise to cross-functional Company initiatives, including development of advanced predictive ADME/PK modeling methodologies and technologies, capability and data growth strategy, and internal/external diligence.

What You’ll Do…

  • Work closely with a team of experienced drug hunters to create novel, differentiated drug candidates, by providing strategic guidance and execution associated with in vitro and in vivo profiling, PK/PD/Effect relationship development, and human dose projection to move programs from target concept to the clinic
  • Partner closely with a team of AI/ML and data scientists to develop and implement a comprehensive and robust platform for in silico prediction of complex PK/ADME properties
  • Together with in vitro ADME leadership, drive a cross-functional strategy aimed at capability refinement and expansion to address growing portfolio needs
  • Identify, qualify, engage, and manage external providers of in vitro ADME and in vivo PK services; analyze and interpret resulting data

What You Bring...

  • Broad DMPK experience and expertise spanning target assessment to the clinic, with an awareness of regulatory guidance and industry trends
  • Leading-edge mindset in relation to current experimental and computational DMPK approaches and techniques. Modeling and simulation expertise preferred (PBPK and QSP)
  • Track record of success rapidly identifying and advancing preclinical development candidates
  • Small molecule drug development experience across multiple indications. Experience in CNS and across multiple modalities a plus
  • Ability to effectively communicate and influence in a matrix environment
  • Success at sourcing and managing CROs to perform in vitro assays and in vivo studies
  • Comfort and productivity in a dynamic, startup environment
  • High-performing team mentality, able to lead, follow, and contribute based on the needs of the team and situation
  • PhD. in a relevant scientific discipline and 10+ years of drug discovery experience or BS/MS and 15+ years

More on Valo

Valo Health, Inc (“Valo”) is a technology company built to transform the drug discovery and development process using human-centric data and artificial intelligence-driven computation. As a digitally native company, Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an integrated set of capabilities designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs across cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Boston, MA, Valo also has offices in Lexington, MA, and New York. To learn more, visit

Company Info.

Valo Health, LLC

Valo Health, LLC (“Valo”) is a tech­nol­o­gy com­pa­ny built to trans­form the drug dis­cov­ery and devel­op­ment process using human-cen­tric data and arti­fi­cial intel­li­gence-dri­ven com­pu­ta­tion. As a dig­i­tal­ly native com­pa­ny, Valo aims to ful­ly inte­grate human-cen­tric data across the entire drug devel­op­ment life cycle into a sin­gle uni­fied archi­tec­ture.

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