We are looking for an enthusiastic and dedicated research assistant to join our team at the CRUK Cambridge Institute (part of the University of Cambridge) to study mRNA translation using bioinformatic approaches. This is an exciting opportunity to contribute to our goal of understanding the molecular mechanisms of gene regulation.
You will be part of a computational team, led by Dr Susanne Bornelöv, which studies gene regulation using various approaches including machine learning, evolutionary genomics, and sequencing bioinformatics. Our team is funded by an 8-year Wellcome Career Development Award (https://wellcome.org/grant-funding/people-and-projects/grants-awarded/data-driven-methods-unravel-hidden-layers-genome).
In this role, you will support our efforts to improve current ribosome profiling analysis workflows and perform large-scale analyses of such data to investigate the role of codon usage in gene regulation. Our ultimate aim is to map the determinants of mRNA translation, including nucleotide sequence, codon composition, and RNA modifications, and to understand how these contribute to development and tissue homeostasis. Although prior experience working on any aspect of gene regulation, including mRNA transcription, translation or turnover would be beneficial, it is not strictly required. The most important qualities we are looking for are strong teamwork skills and a keen interest in computational approaches to uncover fundamental aspects of gene regulation.
To be successful in this role, you will need to have solid programming/scripting skills and an ability to develop workflows and document your work. Applicants should have a BSc or MSc degree in a relevant quantitative discipline and preferably a reasonable amount of research experience. Previous experience working high-throughput sequencing workflows, high-performance computing, version control systems, or with sequencing data such as RNA-seq or Ribo-seq would be desirable, but training can also be provided as needed.
As a member of our team, you will have the opportunity to contribute your own ideas to ongoing research activities. We are committed to providing an inclusive and supportive working environment that fosters intellectual curiosity and scientific excellence.
Fixed-term: The funds for this post are available for 2 years in the first instance.
For more information about the research group, including our most recent publications, please see our website: www.sblab.uk.
The closing date for applications is 29th May 2023. Interviews will be held in the beginning of June. The starting date is flexible, but ideally in September.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please direct any informal enquiries to Dr Susanne Bornelöv (email@example.com).
Please quote reference SW36422 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
The University of Cambridge is a public collegiate research university in Cambridge, United Kingdom. Founded in 1209 and granted a royal charter by Henry III in 1231, Cambridge is the world's third oldest surviving university and one of its most prestigious, currently ranked second best in the world and the best in Europe by QS World University Rankings.