Scientist, Lipidomics

Key Skills

Java Programming, Python Programming, C++, C Programming, SQL, Cloud computing, Scala Programming, Machine learning techniques, Data science techniques, MATLAB Programming, PyTorch, TensorFlow, R Programming

Job Description

In this role, you will play an integral role in the daily activities of the Mass Spectrometry (MS) Innovation Hub at Altos Labs (Bay Area Institute). As a Lipidomics Scientist you will be an integral part of advancing the methods development, research, and projects central to the overall lipidomics effort at Altos Labs. To this end, you will develop and implement methods to identify and quantify lipids for cells, tissues, and other biological fluids. This includes sample preparation (solid phase extraction, liquid-liquid extraction), and measurement using appropriate scan modes on a wide array of instrumentation (orbitrap, QQQ, TOF), for which you will receive training to operate where necessary. You will maintain and troubleshoot instrumentation, as well as perform data analysis using various software programs (commercial and in-house developed platforms). In addition, you will document all sample preparation, method development notes, author scientific reports/publications and protocols/SOPs, present results/findings, and collaborate with research associates/assistants, data scientists, and other junior and senior technical staff throughout Altos Labs.

Who You Are

Minimum Qualifications

The right candidate will have:

• A PhD with a strong analytical background in chemistry, biochemistry, chemical engineering, biotechnology, bioengineering, or related fields. 
• Strong wet-laboratory skills with 3+ years of experience in a research laboratory, using LC-MS instrumentation and analyzing lipidomic data.
• Familiarity with proper experimental designs for untargeted and targeted lipidomics and small molecule metabolomics, including QC procedures, separation techniques, and processing samples from large studies.
• Excellent written and verbal communication skills.
• Strong interpersonal skills and the ability to work as a team with diverse individuals.
• Demonstrate initiative and flexibility.
• Excellent organizational and time management skills with the ability to independently meet project timelines. 

Preferred Qualifications

• Experience with automation platforms for sample preparation, e.g. Tecan Freedom EVO
• Expertise in High-Resolution LC-MS/MS method development for global profiling of lipids in cells, tissues, and other biological fluids. 
• Competency in developing and implementing LC-MS/MS methodologies for targeted analysis of various lipid-types/classes. 
• Proficiency in designing and executing high-throughput lipid biomarker identification and validation studies.
• Experience in Mass-Spec Imaging of human and mouse tissues. 
• Working knowledge of publicly available lipid databases (i.e. Lipid Maps).