Scientist, Proteomics/Post Translational Modifications

Key Skills

C Programming, C++, Cloud computing, Data science techniques, Java Programming, Machine learning techniques, MATLAB Programming, Python Programming, PyTorch, R Programming, Scala Programming, SQL, TensorFlow

Job Description

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives.

Position description:

Calico is seeking an experienced Proteomics Scientist to join the mass spectrometry proteomics group. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. The work will involve multiple mass spectrometry based analyses including proteome profiling and investigation of post translational modifications. You will work with many different sample types, optimize and develop sample preparation and mass spectrometry methods, and be responsible for various research projects. The position will involve driving proteomics research projects as well as working closely with collaborators across labs at Calico. The position is ideal for someone who excels at wet lab but also has some computational biology training.

Responsibilities:

• Lead proteomics method development projects
• Prepare samples from tissues, cells, and biofluids
• Optimize and develop new sample preparation and LC-MS methods for protein/PTM profiling
• Maintain and troubleshoot instruments including HPLCs, mass spectrometers and other bioanalytical equipment
• Proteomics data analysis
• Present results at internal lab meetings and company-wide meetings
• Publish results and present at external scientific conferences

Position requirements:

• Ph.D. in biochemistry/chemistry/biology or related field
• Minimum 3 years technical experience post Ph.D.: post-doctoral or industry
• Strong record of productivity and scientific publications
• Experience in method development for HPLC and/or mass spectrometers
• Experience in proteomics data analysis and R/Matlab/Python
• Experience in proteomics sample preparation
• Experience in maintaining and troubleshooting HPLCs and mass spectrometers
• Experience in post translational modification analysis
• Detail-oriented and organized
• Strong teamwork and communication skills
• Self-motivated with a “can-do” attitude is required for success
• Flexible, able to respond quickly to shifting priorities and able to multitask

Nice to have (valued but not required):

• Experience in chemoproteomics/immunoprecipitation
• Experience in glycoproteomics
• Experience in protein/antigen binding arrays
• Experience in antibody sequencing
• Experience in protein cross-linking
• Experience with Thermo Eclipse/Lumos

Calico requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Calico will consider requests for Reasonable Accommodations.